Mishonga yemRNA inogona kuchinja DNA here?
Mishonga yemRNA inogona kuchinja DNA here?
Anonim

Coronaviruses inotangira kubva kune inotonhora kusvika kune yakanyanya hutachiona seSARS (SARS-CoV) uye MERS (MERS-CoV) uye yazvino Covid-19 (SARS-CoV-2). Parizvino hapasati pave neFDA-yakatenderwa yekudzivirira yekudzivirira hutachiona hwe coronavirus. Aya ese ane FDA mvumo yekushandisa emergency.

Miviri yemishonga yekudzivirira yeCovid-19 inowanikwa muUS inoshandisa messenger RNA tekinoroji kudzivirira kana kuderedza zviratidzo zvehutachiona hweCovid-19. Iyi tekinoroji yekudzivirira yemRNA itsva; migumisiro yeDNA yakachinjwa, kana iripo, haizivikanwi. Nekudaro, vamwe, kusanganisira CDC vakati hutachiona hwaisazobatana neDNA.

Mamwe masayendisiti anotenda kuti mRNA vaccine inogona kupinda uye kushandura zvachose DNA. Kufanana nemajekiseni eDNA, majekiseni eRNA anoshandisa chikamu cheiyo genetic code yehutachiona kuita kuti immune system ipindure.

Chinyorwa parizvino chiri preprint (chisati chaongororwa nevezera) chinokurukura chidzidzo chemurabhoritari umo zvimwe zvidimbu zveCovid-19 RNA zvakashandurwa kuita DNA ndokuzobatanidzwa mumakromosomes evanhu.

Medical Daily yakataura nemunyori anotungamira Rudolf Jaenisch, MD. Mumwe muzvinafundo weBiology kuMIT, Dr. Jaenisch, akaita ongororo yekutanga achiratidza kuti kukanganiswa kwemajini kunogona kugadziriswa mumakonzo. Parizvino ari kushanda paParkinson, Alzheimer's, autism uye kenza muvanhu. Akahwina mibairo yakawanda yebasa rake, kusanganisira iyo Wolf Prize muMishonga.

MD: Ko ongororo yako yazvino inoratidza kuti Covid-19 mRNA vaccine inogona kukuvadza DNA muvanhu?

Dr. Jaenisch: Kwete humbowo hwekukuvara. Iyo mRNA inogona kubatana muDNA uye pamwe kuratidzwa asi hapana humbowo hwakananga hwacho.

MD: Kana mishonga yekudzivirira mRNA ichigona kusanganisa muDNA yevanhu izvi zvingarevei kune ramangwana?

Dr. Jaenisch: Ichava tekinoroji yekubudirira. Zvinozoshandura nzira dzekurapa zvirwere.

MD: MRNA kana DNA vaccine ichachinja sei marapiro?

Dr. Jaenisch: Iyi mRNA Covid-19 yekudzivirira ndiyo yekutanga kuratidza kuchengetedzeka uye kushanda kwerudzi urwu rwekurapa. Kana paine humbowo hwakakwana hwekuti tekinoroji iyi yakachengeteka uye inoshanda saka izvi zvine mukana wakakura weramangwana rekurapa zvirwere zvakawanda.

Basa reJaenisch lab rinogona kutsanangurawo kuti sei varwere vakapora kubva kuCovid-19 vachiri kuongororwa kuti vane chirwere ichi, kunyangwe mwedzi gare gare, sekureva kwenhau yeABC. Kana hutachiona hwakagadzirisa DNA yevarwere, saka ruzivo rwayo rwemajini runogona kunge rwuchiri kushanda. Iyo Jaenisch lab yakaona kuti hutachiona hwakashandisa enzyme inonzi LINE-1 kudzokera muchitokisi kuti iite zvakare. LINE-1 inowanikwa nyore nyore mugenome yemunhu.

Nezve kana mishonga yemRNA inogona kushandura DNA, Dr. Jaenisch anofunga kuti chingave chinhu chakanaka. Anofunga zvakare tekinoroji nyowani iyi ichatungamira nzira yekubudirira kurapwa kwezvirwere zvakawanda zvinobata vanhu. Sezvo Dr. Jaenisch vanga vachidzidza nezveDNA mugomarara uye zvirwere zvetsinga kwemakumi emakore, zvaanofunga zvingangove zvakapfuura zvatinoziva vakawanda vedu.

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