Mushonga Inogona Kumisa Kupararira Kwekenza Yemazamu Katatu-Negative
Mushonga Inogona Kumisa Kupararira Kwekenza Yemazamu Katatu-Negative
Anonim

Kirasi yemishonga yakatobvumidzwa neU.S. Food and Drug Administration yekurapa mamwe marudzi egomarara inogonawo kudzivirira kenza yemazamu ine katatu isina kunaka kuti isapararire, maererano neongororo yakabudiswa muNature Communications.

Kurapwa kwegomarara rezamu kwakawanda kunonangana izvo zvinozivikanwa semareceptor mumasero egomarara, kusanganisira estrogen, protesterone, uye HER-2/neu gene, zvisinei, iyo katatu-negative fomu haina aya mareceptor, saka marapirwo acho haana zvinangwa., uye haisi kushanda, maererano neMayo Clinic, iyo yakaita tsvakurudzo. Katatu-negative kenza yemazamu ine CDK 4/6, iyo inodzora puroteni inozivikanwa seSNAIL iyo yakabatana negomarara metastasis. Kirasi yemishonga inodzivisa CDK 4/6 inogonawo kumisa kenza yemazamu katatu isina kunaka kuti isapararire.

Vatsvaguri vakaedza mishonga iyi mumhando dzakasiyana-siyana dzegomarara rezamu, kusanganisira imwe mhando apo bundu rakaiswa mugonzo rine immune system isina simba kuti vaone kuti ndeupi mushonga, kana musanganiswa wemishonga, ungangonyanya kushandira murwere wemunhu.

mapiritsi

Maererano nemunyori mukuru wekudzidza, Zhenkun Lou, Ph.D., pane zvishoma zvakawanikwa nesayenzi pakudzivirira kenza metastasis - chikonzero chikuru chekufa kubva kuchirwere. Kuwanikwa, kana kwakasimbiswa, kunogona kureva nzira itsva dzekushandisa zvinodhaka zvinonzi CDK 4/6 inhibitors, izvo zvinogona kudzivirira kupararira kwemamwe akawanda kenza ane huwandu hwepamusoro hweprotein yeSNAIL, maererano nekuburitswa kwenhau kubva kuMayo Clinic.

"Izvi zvakawanikwa zvinogona kupa kurapa kutsva kwekudzivirira cancer metastasis," akadaro munyori-munyori wekudzidza Matthew Goetz, MD, mukuburitswa. "Mayo Clinic ikozvino iri kugadzira zvidzidzo zvitsva zvinotarisa basa reCDK 4/6 inhibitors uye kukwanisa kwavo kudzivisa kenza metastasis muvakadzi vane katatu-negative kenza yemazamu avo vari pangozi yakanyanya yekenza metastasis."

Vanosvika gumi nevaviri muzana vevakadzi vemuUS vanozoita gomarara rezamu rinopinda mukati mehupenyu hwavo hwose, maererano nebreastcancer.org. Muna 2017, vanenge 40, 610 vakadzi muU.S. vanotarisirwa kufa nechirwere.

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