Kurapa Kwevana Nzungu Allergy Inofambisa Nhanho Padyo NeOral Immunotherapy
Kurapa Kwevana Nzungu Allergy Inofambisa Nhanho Padyo NeOral Immunotherapy
Anonim

Vana vanoitwa oral immunotherapy kuti varape kusawirirana kwavo kwenzungu vanogona kuona budiriro huru mukudzikisira mhinduro yemuviri wavo, sekureva kweongororo nyowani kubva kuYunivhesiti yeCambridge.

Kusawirirana nezvokudya kwazova chimwe chinhu chiri chinetso chinotiza munyika dzokuMadokero. Pakati pa1997 na2008, kuwanda kwakawedzera zvakapetwa katatu, nezvokudya zvisere pari zvino zviri kuita 90 muzana yezvese zvinosawirirana nezvokudya: mukaka, mazai, nzungu, nzungu dzemiti, soya, gorosi, hove, nehove. Kusawirirana nenzungu ndiko kwakanyanya pakati peizvi, zvichibata chikamu chinodarika chikamu chimwe kubva muzana chevanhu. Uye nepo kurwadziswa kwechikafu kuchisanganisira zvinopfuura mazana maviri ezviuru zvekushanyira zvipatara pagore, hapasati pave nemushonga.

Zvichida nzira yakanakisa yekurapa kusawirirana kwenzungu mumakiriniki magadzirirwo ndeye oral immunotherapy (OIT), nzira inosanganisira kudzvanya immune system yemurwere - uye nekudaro, mhinduro yemuviri wavo kune allergies - kuburikidza nemuromo zvakatorwa zveallergen. Muchidzidzo chezvino, iyo yakatorwa yaive peanut protein, inopihwa pakuwedzera mazinga pamusoro pe26-vhiki. Boka rinodzora rakagamuchira placebo panguva iyoyo.

Pakupera kwechidzidzo ichi, timu yakaona kuti 84 kusvika 91 muzana yevana vaigona kushivirira zvakachengeteka 800 mg yeprotein yenzungu inonwiwa zuva nezuva - yakaenzana nenzungu shanu. Kuchiita sekuwedzera kusingakoshi, kusvetuka ikoko kwakaratidza kuwedzera kwe25-kushivirira kwevana kubva pakutanga kwechidzidzo.

"Kurapa uku kwakabvumira vana vane huipi hwese hwekusawirirana kwenzungu kuti vadye huwandu hukuru hwenzungu, pamusoro pemazinga anowanikwa muzvokudya zvakasvibiswa uye kudya, kuvasunungura ivo nevabereki vavo kubva mukutya kwehupenyu hunogona kukanganisa hupenyu," akatsanangura kudaro mutungamiri wekudzidza Dr. Andrew Clark, weCambridge University Hospitals, mukutaura.

Clark nevamwe vake vakapedza makore akati wandei apfuura vachitsvaga OIT senzira inoshanda yekurapa kusawirirana kwenzungu. Muna 2011, timu yake yakaratidza kuvandudzwa kunoshamisa kwe1, 000-mudiki muyedzo yekiriniki yakaitika mukati memakore matatu. Chidzidzo chezvino chaive nemhedzisiro isinganyanyi kushamisa, asi zvakadaro zvakapa timu tariro yakawanda. Mushure memwedzi mitanhatu yekurapa, makumi maviri neina pavana makumi matatu nevapfumbamwe (62 muzana) vakagamuchira OIT muchikamu chekutanga vakakwanisa kushivirira dhigirii rezuva nezuva re1400 mg yeprotein yenzungu - yakaenzana negumi nzungu uye yakakura kwazvo huwandu hweprotein yenzungu kupfuura zvaizoita. netsaona kuwanikwa muchikafu.

Zvisinei, pakava nokumwe kwakashata. Vanosvika 20 muzana yevatori vechikamu vakanzwa kukwenya nemuromo, uye chidzidzo chimwe chete chaifanira kubuda muchidzidzo mushure memadhosi maviri eOIT chete. Nyaya yacho yaida adrenaline kudzikamisa zviratidzo zvake.

Nepo vaongorori vachibvuma kudzidza kwavo kunoratidza chivimbiso chekushandiswa kwakapararira kweOIT, vanobvuma kuti nzira yacho haisati yagadzirira kushandiswa mudzimba. "Chidzidzo chikuru ichi ndicho chekutanga cherudzi rwayo munyika kuva nemigumisiro yakanaka zvakadaro, uye inokosha kufambira mberi mukutsvakurudza kwepeanut allergy," akadaro munyori pamwe chete Dr. Pamela Ewan mukusunungurwa. "Zvisinei, zvimwe zvidzidzo mu vanhu vakawanda vari kudiwa. Zvakakosha kuziva kuti OIT haisi mishonga iyo vanhu vanofanira kuedza ivo pachavo uye inofanira kuitwa chete nenyanzvi dzezvokurapa mumamiriro ezvinhu enyanzvi."

Zvinhu zvishoma hazvisati zvazivikanwa kune vaongorori, uye vamwe vanofungidzira kuti kupindura mubvunzo wekushandiswa kwekiriniki kunogona kuitwa chete kuburikidza nekufumura zvakavanzika izvi kutanga. "Mapoka evanoferefeta anoda nguva yekunatsa maprotocol, kusimbisazve data, kunzwisisa maitiro eOIT, uye kuderedza mhedzisiro," akanyora Matthew Greenhawt, weYunivhesiti yeMichigan Food Allergy Center, mune inofambidzana.

Zvakadaro, kukunda zvipingamupinyi izvi ibhiriji Clark anoziva kuti rinoyambutswa zvakanaka mune ramangwana. Ruzhinji rwevana 99 vanoita chidzidzo chake vakaona kuvandudzwa kukuru kwehupenyu hwavo. Uye mabhenefiti haana kugumira ipapo. "Mhuri dzakabatanidzwa muchidzidzo ichi dzinoti zvakashandura hupenyu hwavo zvakanyanya" zvakare, Clark akadaro.

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