Mushonga Wemhanza Inogona Kurara MuMasero Eganda Edu, Mafuro Ebvudzi Akakurazve Achishandisa Stem Cells Kekutanga
Mushonga Wemhanza Inogona Kurara MuMasero Eganda Edu, Mafuro Ebvudzi Akakurazve Achishandisa Stem Cells Kekutanga
Anonim

Varume vese, zvisinei nekuti vadiki kana vakuru sei, vanotya kutanga kwemhanza uye vachaita chero chinhu musimba ravo kudzosera kumashure kana kudzivirira mafollicle ebvudzi kubva kutetepa. Imwe ongororo kubva kuYunivhesiti yePennsylvania yePerelman Chikoro cheMishonga yakashandisa masero epithelial stem masero kudzoreredza vhudzi rakarasika kana kufa mumakonzo kekutanga munhoroondo yekurapa.

Maererano neAmerican Academy of Dermatology, rudzi rwakajairika rwekurasikirwa kwebvudzi, kana alopecia, kurasikirwa kwebvudzi renhaka uko kunobata varume nevakadzi vanosvika mamirioni makumi masere muUnited States. Kurasika kwebvudzi, kunozivikanwawo sechirume pateni-mhanza muvarume uye pateni-mhanza yevakadzi muvakadzi, parizvino inorapwa kuburikidza nemafambisirwo ebvudzi, mimwe mishonga yemishonga, kuderedza ganda remusoro kana kuvhiyiwa kwekuwedzera, kana michina yelaser inoburitsa mwenje welaser unokwanisa kumutsa bvudzi. kukura.

"Aka ndekekutanga chero munhu agadzira masero epithelial stem masero anokwanisa kugadzira epithelial chikamu chebvudzi," Dr. Xiaowei "George" Xu, purofesa wePathology uye Laboratory Medicine uye Dermatology paPerelman School of Mushonga wakadaro mukutaura.

Xu nevamwe vake vekuPenn neNew Jersey Institute of Technology vakawedzera majini matatu kumasero eganda remunhu, anozivikanwa sedermal fibroblasts, achinyatsoashandura kuita induced pluripotent stem cells (iPSCs). iPSCs inogona kutevedzera chero sero mhando mumuviri wemunhu. Nekudaro, idzi iPSC dzakashandurwa kuita epithelial stem masero (EpSCs).

Pakasanganiswa maEpSC aya achangobva kushandurwa nemamwe maseru akaiswa mumakonzo ane immune system yakakanganiswa, kwete chete maEpSC akaisirwa akaburitsa kunze kweganda ganda uye follicles mumakonzo aive akafanana nebvudzi revanhu, asi ivo vakabudirirawo kugadzira bvudzi shaft. Aya mashefu ebvudzi anosimbisa kugona kwebvudzi rekuvandudzwa. Mukati memazuva gumi nemasere kubva pakatanga chidzidzo, makumi maviri neshanu muzana ePSCs akashandurwa kuita EpSCs.

"Kana munhu akarasa bvudzi, anorasikirwa nemhando dzose dzemasero." Xu akatsanangura. "Takagadzirisa dambudziko guru, epithelial chikamu chebvudzi rebvudzi. Isu tinofanirwa kutsvaga nzira yekugadzira masero matsva epapillae, uye hapana ati afunga kuti chikamu ichocho."

Xu akawedzera kuti masero aya haangogumiri pakuvandudza bvudzi uye anogona kushandiswa mune akati wandei mamiriro anosanganisira zvekuzora uye maronda ekuporesa. Nekudaro, timu yekutsvagisa yakabvuma kuti miedzo yevanhu inosanganisira kuisirwa EpSC iri kure. Nhanho inotevera mukutsvagisa kwavo ichatarisa kuyedza maitiro akafanana padermal papillae, rudzi rwechipiri rwevakuru stem cell.

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