Kurapa HIV Rimwe zuva Kunogona Kusanganisira Monoclonal Antibodies
Kurapa HIV Rimwe zuva Kunogona Kusanganisira Monoclonal Antibodies
Anonim

Itsva yakaburitswa pamhepo nhasi muNature inopa humbowo hwekuti monoclonal antibodies - 'designer molecules' inogadzirwa murabhoritari kunangana nechirwere chaicho - inogona kunge iri kurapa kunoshanda pakurapa kwehuman immunodeficiency virus (HIV).

"Data redu rinoratidza, kekutanga, kurapa kwakadzama kweakawanda uye ane simba eHIV-yakananga monoclonal antibodies muRhesus tsoko dzinogara dzakatapukirwa nehutachiona hwehutachiona hwe simian-human immunodeficiency virus," munyori anotungamira wechidzidzo, Dan H. Barouch, MD, Ph.D., director weVaccine Programme kuRagon Institute yeMGH, MIT, uye Harvard, akadaro mukuburitswa kwenhau.

Simian-human immunodeficiency virus ishanduro yeHIV inowanikwa mutsoko.

Chii chinonzi monoclonal antibodies?

Kuti unzwisise mashandiro anoita monoclonal antibodies, zvinodikanwa kuti unzwisise maitiro e immune system. Dziviriro yemuviri inorwisa uye inoparadza zvinhu zvekunze. Kunyanya, muviri unopindura kuunzwa kwemapuroteni ekunze, anonzi maantigen, nekugadzira masoja ekudzivirira chirwere. Antibody ipuroteni inoshanda se 'marker' chaiyo kune antigen. Inotenderera mumuviri kusvikira yawana uye inozvibatanidza kune antigen, uye mushure mekusungira kwairi, molecule inogona kuonekwa uye kuparadzwa ne phagocytes, iyo inoparadza masero ane antigen.

Murabhoritari, musayendisiti anogona kugadzira makopi akawanda emasoja ekudzivirira chirwere anonzi monoclonal antibodies (mAbs). Masero 'emonoclonal' anogadzirwa nekudzokororwa kudzokororwa kwesero rimwe chete rinotangira. Mumakore makumi maviri apfuura, maAbs akagadzirirwa kunanga imwe antigen, senge inowanikwa pamasero egomarara, uye saka anga achibatsira mukurapa chirwere.

Murapi wenguva dzose wevarwere vane HIV, kunyange zvakadaro, mushonga unoderedza utachiona hweHIV. Mishonga iyi, zvisinei, ine zvimhingamupinyi: haikwanise kurapa utachiona hweHIV uye, kunyangwe ichishanda kuvarwere vazhinji, inogumira nekuda kwekuramba uye chepfu. Mumakore mashoma adarika, vatsvakurudzi vakatanga kuona masoja ekudzivirira chirwere semushonga mutsva unogona kurapa HIV nekuti aizoshanda nenzira yakasiyana neyemishonga yemaARV.

Masoja ekudzivirira chirwere anonangana neutachiona husina utachiona pamwe chete nemaseru ane utachiona, nepo maantiretroviral aripo anongotadzisa utachiona,” anotsanangura kudaro Barouch. "Maantibodies anogona, naizvozvo, kupa imwe nzira yekurapa yakasiyana-siyana inogona kusanganiswa nemishonga inoderedza hutachiona."

Muchidzidzo chepreclinical - icho chisingasanganisire vanhu - Barouch nechikwata chake vakapa cocktail yeHIV-specific maAbs kana single mAbs muRhesus tsoko dzaigara dzakatapukirwa ne simian-human immunodeficiency virus.

"Kurapwa kwemasoja ekudzivirira chirwere kwakakonzera kudzikira nekukurumidza kwehutachiona muropa uye munyama dzetsoko dzine hutachiona," anodaro Barouch. Kutevera kuisirwa kamwe chete kwemasoja ekudzivirira chirwere, huwandu hwehutachiwana hwakadzika zvakanyanya kusvika pamazinga asingaonekwe mukati memazuva matatu kusvika manomwe. Chikwata chevaongorori chakawanawo huwandu hwehutachiona hunoenderana nesero hudzikiswe muropa, lymph nodes, uye mudumbu.

Zvinonyanya kushamisa, kuisirwa antibody kwakawedzera mhinduro dzetsoko dzekurwisa hutachiona, hwairatidza kuve nerubatsiro rwenguva refu. Vatsvagiri vacho vakacherekedza kuti kazhinji, hutachiona hunowedzera kana maantibody titers aramba mushure meimwe nguva (mazuva makumi mashanu nenhanhatu epakati), asi zvimwe zviitiko zvakaratidza. "Zvinotoshamisa ndezvokuti, chidimbu chemhuka dzine hutachiwana hwakadzikira hwakaramba husingaonekwe kwenguva yakareba yekudzidza, pasina imwezve infusions," Barouch akadaro mukuburitswa kwenhau.

Vatsvagiri vanotenda kuti data ravo rinogona kukurudzira kuvandudzwa kwemamonoclonal antibodies-based therapies eHIV muvanhu.

"Monoclonal antibodies pamwe chete nemishonga inorwisa mabhakitiriya inogona kuongororwa kuti iwedzere kurapwa, pre- uye post-exposure prophylaxis, uye nzira dzekupedza hutachiona hweHIV muvanhu," Barouch akadaro mukuburitswa kwenhau.

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