Masayendisiti Anoderedza Kenza Yeuropi NeNovel Gene Regulation Technology
Masayendisiti Anoderedza Kenza Yeuropi NeNovel Gene Regulation Technology
Anonim

Mushonga mutsva unobva kuNorthwestern University unodzikisa chimiro chisingarapike chegomarara reuropi mumakonzo, zvichigadzira nzira yekurapa kunobvira kwechirwere ichi chinoparadza.

Nekuda kwekuzvivharira kwavo, kuvigwa mukati mukati meganda rehuropi risina kusimba uye rakavharirwa kuseri kwenhare iri dehenya, mamota ehuropi anowanzo kuoma kubvisa nekuvhiyiwa nedzimwe nzira dzakajairwa dzekurapa cancer.

Uku kushomeka kwemushonga wakanaka kunonyanya kurwadza kweglioblastoma multiforme (GM), bundu remupfungwa rinokura nekukurumidza uye rinokwanisa kusvika pakukura risati raita zviratidzo.

Kunyange zvazvo GM isingawanzoitiki - 16, 000 zviitiko zvitsva gore negore - 90 muzana yevarwere vanokundwa nechirwere mukati memakore mashanu. Mushakabvu Sen. Edward Kennedy aive mumwe akabatwa neglioblastoma multiforme.

Ese magomarara anokonzerwa nekuchinja kwemajini, uye vaongorori vakagadzira nzira yekucheka-cheka kunanga avo vane chekuita nekukura kwehasha kwemamota eglioblastoma.

Vakashandisa spherical mabara akagadzirwa negoridhe nanoparticles uye genetic zvinhu zvinonzi RNA kushandura shanduko yeGM genes yaimhanya amok. RNA ihama yepedyo kune iyo inonyanya kuzivikanwa DNA, uye mamwe marudzi echinhu ichi anogona kubatidza nekudzima majini.

Mabhora ane nano-saizi eRNA madiki zvekuti anogona kuverevedza nepakati pehuropi hweropa, sefa yechisikigo inodzivirira pfungwa kubva kune zvinokuvadza muropa asi inogona zvakare kukanganisa mishonga inoponesa hupenyu.

"Uyu muchato wakanaka wehunyanzvi hutsva hune majini echirwere chinotyisa," akadaro munyori-munyori mukuru Dr. Chad Mirkin, nyanzvi yenanomedicine uye purofesa wemakemikari kuNorthwestern.

Mirkin akakwenenzvera hunyanzvi hwekugadzira mabhora akatenderera eRNA muna 1996, ndokuzobatana nenyanzvi yeglioblastoma Dr. Alexander Stegh, wekuNorthwestern, uyo muna 2007 akawana shanduko inobatsira gomarara kurwisa kurapa kwakajairika.

"Boka rangu rekutsvagisa riri kushanda kuburitsa zvakavanzika zvegomarara uye, zvinotonyanya kukosha, nzira yekuimisa," akadaro Stegh, munyori-mukuru pakudzidza. "Runako rwejini ratakanyaradza - Bcl2Like12 - nderekuti rinotamba mabasa mazhinji akasiyana mukuramba kurapwa. Kubvisa majini pamufananidzo kunofanira kubvumira marapiro enguva dzose kuva anobudirira zvikuru.”

Kudzima Bcl2Like12 gene kwakaderedza bundu saizi 3-4 kupeta mumakonzo uye kwakawedzera huwandu hwavo hwekupona ne20 muzana, chirevo chinodaro.

Glioblastoma igomarara rakaoma kwazvo, uye mishonga yakawanda yechemo-therapeutic inokundikana mukiriniki, sekureva kwaStegh.

"Dambudziko rimwe chete nderekuti pane rondedzero yakakura yemajini asina kurongeka mune glioblastoma, asi isu hatina nzira yekunangana nayo yese tichishandisa nzira dzemishonga," Stegh akadaro. "Isu tinofunga kuti nanomaterials inogona kuita basa rakakosha kutibvumira kuita zano remunhu mushonga mukurapa cancer."

Iwo nanoparticles aive akashongedzerwawo tracker - gadolinium - inobvumidza kuonekwa necerebral MRI scans. Heino 3-D kuvakwazve kwemagineti resonance mifananidzo mushure me intracranial jekiseni regadolinium-functionalized spherical nucleic acids.

Vhidhiyo inotenderwa neScience Translational Medicine/AAAS naJensen SA, Day ES, Ko CH, et al. 2013.

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