Epilepsy Yakarapwa Mumbeva, Kubatwa nepfari Kwakamira Mushure mekuvhiyiwa kweSero
Epilepsy Yakarapwa Mumbeva, Kubatwa nepfari Kwakamira Mushure mekuvhiyiwa kweSero
Anonim

Mukuedza kugumisa migumisiro inonetesa yokubatwa nepfari kunoramba kuchiitika uye kurapa kusingashandi kuvarwere vepfari, kuisirwa sero kungava chinhu chinokosha.

Vatsvagiri kubva kuYunivhesiti yeCalifornia San Francisco (UCSF) vakaburitsa chidzidzo muna Chivabvu 5 muNature Neuroscience inotsanangura imwe-nguva medial ganglionic eminence (MGE) cell transplant yakakwanisa kudzora kubatwa kwemakonzo nepfari. MGE masero imhando yemasero ekutanga anogona kusiyanisa kuita interneurons, kana masero etsinga anodzivisa kusaina.

Kutapurirana kwaidzivirira kusaina kusaina kwemaseru etsinga uye kwakaitwa munzvimbo yehippocampus yehuropi iyo ine basa rekudzidza nekurangarira mabasa uye yakabatana nekugwinha.

"Masero aya anofamba zvakanyanya uye anobatanidza muuropi hwevakuru semaneuron matsva ekudzivisa," akadaro Scott Baraban, purofesa anogara pakuvhiyiwa kwetsinga paUCSF. "Uyu ndiwo mushumo wekutanga mumuenzaniso wembeva wevakuru vepfari umo mbeva dzainge dzatove nepfari dzakamira kubatwa nepfari mushure mekurapwa."

Zvipfari zvinozivikanwa kuti zvinoita kuti tsandanyama dzibatane uye, mune dzimwe nguva, kurasikirwa nepfungwa uye kuzvidzora izvo zvinogona kukonzera kukuvara kwakakomba. Mamiriro acho mhedzisiro yekupfurwa kwakanyanya uye kusajairika kwemasaini etsinga muuropi.

Vatsvakurudzi vakadyara masero aya ekudzivirira, ayo akakwanisa kuderedza zviratidzo zvisingadzoreki, kubvisa kubatwa muhafu yemakonzo uye nekuderedza zvakanyanya kubatwa kwechimbichimbi mune imwe hafu. Kunyanya, masero eMGE akatorwa kubva kumbeva embryos uye, paakaiswa, akatama uye akaberekera mukati meinterneurons kugadzirisa iyo yakatyoka neural system mumakonzo epfari.

Muchidzidzo chekare chakabudiswa muna May 2 mumagazini Cell Stem Cell, vatsvakurudzi veUCSF vakashandurawo masero e-pluripotent stem masero anoratidza MGE-akafanana nemaitiro murabhoritari yavo uye zvakafanana akashanda semasero anodzivisa nerve kana akasimwa mumakonzo ane utano. Kuwana uku kunogona kubatsira vaongorori kufumura mabasa emasero mukurapa neural kusagadzikana.

Zvimwe zvakanaka zvakabuda kubva kuongororo ichangoburwa yaisanganisira kuderedzwa kushushikana uye hyperactivity mumakonzo. Mbeva dzakaitawo zvirinani muzviitwa zvakaedza kudzidza kwavo nehunyanzvi hwekuyeuka.

Mune imwe ongororo, kufambira mberi kwakawanda kwakaitwa kubatsira kufanotaura kubatwa kwevarwere vane pfari vanoganhurwa nemaitiro ekurapa aripo. Muchiitiko ichi, ma electrode anovhiyiwa akaiswa pakati pedehenya nehuropi uye anotaurirana kune imwe electrode muchipfuva. Iyo data yakaunganidzwa kubva pachigadzirwa ichi inotarisisa kana kubatwa kungangoitika.

Sekureva kweCenters for Disease Control and Prevention (CDC), zvikamu zviviri muzvitatu zvevanhu vane pfari vanowana mibairo yakanaka kuburikidza nekushandisa zvinodhaka kudzora kubatwa, nepo vanhu vasara vanongobatsirikana zvishoma uye vanosangana nekudzokorora kwepfari. Zvisinei, vatsvakurudzi vanoti dzimwe nzira dzekurapa idzi hadzina kukosha zvachose.

"Migumisiro yedu inhanho inokurudzira yekushandisa inhibitory neurons pakusimwa kwesero kune vanhu vakuru vane maitiro akaoma epfari," akadaro Barbaran. "Iyi nzira inopa mukana wekudzora pfari uye kununura kushaikwa kwenjere muvarwere ava."

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