Yakaderera Melatonin Secretion Inofanotaura Rudzi 2 Dambudziko reShuga
Yakaderera Melatonin Secretion Inofanotaura Rudzi 2 Dambudziko reShuga
Anonim

Kuderera kwe melatonin, hormone inobatsira kugadzirisa kurara, inogona kufanotaura njodzi yechirwere cheshuga yerudzi rwechipiri.

Type 2 chirwere cheshuga chave chave chakabatana nekusakwana kwekurara, uye chidzidzo chitsva chakaitwa paBrigham neWomen's Hospital (BWH) muBoston chinowona kuti kuderera kwe melatonin secretion kunoenderana nekuwedzera njodzi yechirwere. Chidzidzo ichi chakaburitswa muna Kubvumbi 3 chinyorwa che Journal of the American Medical Association.

Melatonin, inogadzirwa nepineal gland yehuropi ichibva yaburitswa muropa, inoita basa guru mukudzora kutenderera kwemuviri zuva nezuva. Mahomoni ehomoni anowanzokwira maawa akawanda mushure mokunge munhu arara, uye anoderera kusvika pakumuka.

Kutenderera kwekurara/kumuka kune hukama nemabasa mazhinji akakosha emuviri, uye tsvakiridzo yapfuura yakaratidza kuti melatonin ine basa mumetabolism yeglucose, muitiro unotadza kushanda zvakanaka muvarwere veshuga. Zvinoenderana neruzivo rwekumashure kwechikwata cheBWH, melatonin receptors iripo mupancreas, iyo inoburitsa insulin. Kuchinja kwemajini mu melatonin receptors kwakabatanidzwa ne insulin kuramba uye mhando 2 yechirwere cheshuga, uye kushayikwa kwehope kwakabatanidzwa nekuwedzera insulin kuramba.

"Ino inguva yekutanga kuti sangano rakazvimirira rakagadzwa pakati pehusiku melatonin secretion uye Type 2 chirwere cheshuga," akadaro munyori coauthor Dr. Ciaran McMullan, weBWH's Renal Division uye Kidney Clinical Research Institute, mune chirevo.

"Tinovimba kuti chidzidzo ichi chichaita kuti tsvakurudzo yeramangwana iongorore kuti chii chinokonzera kubuda kwe melatonin yemunhu uye chii chinonzi melatonin pakuchinja glucose metabolism uye njodzi yechirwere cheshuga."

Chidzidzo ichi chakaongorora data yebiological kubva kuvakadzi mazana matatu nemakumi manomwe vane Type 2 chirwere cheshuga uye 370 vasina chirwere cheshuga vakaenderana nezera uye rudzi, zvese chikamu cheNurses' Health Study. Vatori vechikamu vakapa weti neropa samples muna 2000, uye vaongorori vakazovatevera mumakore gumi anotevera kuti vaone kuti vangani vakagadzira chirwere cheshuga chechipiri.

Mhedzisiro yakaratidza kuti vatori vechikamu vane mazinga akaderera ehusiku melatonin secretion vaive nekaviri njodzi yekuva nechirwere cheshuga cherudzi rwechipiri zvichienzaniswa nevaya vaive nepamusoro-soro yehusiku melatonin. Kunyangwe mushure mekufunga nezverumwe rudzi rwechipiri rwechirwere cheshuga zvine njodzi senge genetics, body mass index, uye mararamiro emhando sekudya, kurovedza muviri, uye nguva yekurara, yakaderera melatonin secretion yaive ichiri yakakosha njodzi.

25.8 mamiriyoni eAmerica ane chirwere cheshuga, maererano ne2011 National Diabetes Fact Sheet, pamutengo wepagore we $ 245 bhiriyoni mumari yekurapa uye kurasikirwa nekubudirira.

Vatsvagiri vanoronga kuongorora kana yakaderera melatonin secretion inogona kukonzera zvakananga Type 2 chirwere cheshuga, uye ndedzipi nzira dzinogona kunge dziri kushanda. Kana paine causal mhedzisiro, melatonin yekuwedzera kana zvakanyanya kudzorwa kurara routines zvinogona kuderedza insulin kusamira uye Type 2 chirwere cheshuga.

"Kusarara zvakakwana, kusarara zvakanaka, kusanganisira kutadza kufema munhu akarara, uye kutadza kurara-kumuka kwakadai seaya anoitika mumashifiti zvese zvakabatanidzwa nenjodzi yakawedzera yechirwere cheshuga cherudzi rwechipiri," akadaro muongorori wehope Eve Van Cauter weYunivhesiti ye. Chicago kuenda kuUSA Nhasi.

"Tsika dzakanaka dzenguva dzose dzekurara uye kudzivirira kuvhenekerwa kwechiedza munguva dzemasikati zvichabatsira kubudisa melatonin uye zvinogona kuderedza dambudziko rekutanga chirwere cheshuga chechipiri."

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