Cholesterol-Kudzikisa Ziso Madonhwe Zvakare Kurwisa Upofu muVakuru
Cholesterol-Kudzikisa Ziso Madonhwe Zvakare Kurwisa Upofu muVakuru
Anonim

Ongororo yakaitwa neCell Press yakaongorora kuti cholesterol inoiswa sei mumasero machena eropa anozivikanwa semacrophages aikonzera sei hupofu kune vakwegura. Chikwata chevatsvakurudzi chakaongororawo mishonga ingangove yechirwere ichi kusanganisira fomu rekudonhedza ziso rinogona kuderedza mhedzisiro.

Age-related macular degeneration, AMD, chirwere cheziso chinorwisa zvishoma nezvishoma chiratidzo chepakati chinodzorwa nemacula. Ndiyo inonyanya kukonzera upofu muvanhu vanopfuura makore makumi mashanu uye njodzi inowedzera kana munhu achikura.

Zvidzidzo zvepakutanga zvakaratidza kuvakwa kwe macrophage cholesterol uye kukura kusingaite kwetsinga dzeropa izvo zvinozopedzisira zvakonzera upofu.

"Kuwedzera kunzwisisa kwedu kwechikamu checholesterol mukukura kwetsinga dzeropa kwakatibatsira kuona nzira dzekurapa dzinochinjika, kuvhura nzira dzekurapa kutsva kunogona kutibatsira kudzivirira upofu hunokonzerwa nekuderera kwemacular," anodaro munyori mukuru wezvidzidzo Rajendra Apte weWashington University School of. Mushonga

Apte nechikwata chake chekutsvagisa vakatora macrophage samples kubva kumakonzo echikuru uye vanhu vane AMD uye vakaongorora maitiro avo ebhayoloji uye mamiriro. Vakaona kuti masero machena eropa aive nemazinga akaderera eABCA1, puroteni inoshandiswa kutakura cholesterol kubva mumasero. Pasina kukwanisa kufambisa cholesterol kubva mumacrophages, tsinga dzeropa dzinokura muhuwandu kusvika pakupedzisira hwakonzera upofu.

Mbeva dzechikuru dzine AMD dzakapihwa marudzi maviri echolesterol regulators, Liver X Receptor uye microRNAs-33. Mumhinduro yeziso uye jekiseni, ese ari maviri makomisheni akabatsira kune ABCA1 mapuroteni mazinga izvo zvakazobatsira kuderedza cholesterol kuwanda mumasero machena eropa.

"Kusajairika kwetsinga yeropa hunhu husiri hwe AMD chete, asiwo maitiro ezvirwere zvakasiyana-siyana kunze kweziso, kusanganisira kenza uye atherosclerosis, izvo zvine chekuita nekurwara kwakanyanya uye kufa," Apte anodaro. "Zvatinowana zvinogona kunge zvine zvakakosha mukunzwisisa kwedu pathobiology yemamiriro aya."

Chidzidzo chose chakabudiswa muna April 2 edition yemagazini Cell Metabolism.

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