Masero Anodzivirira Dziviriro Paganda Anogona Kusimba Paganda Kupfuura MuRopa, Majekiseni Asingasviki Netsono Ramangwana?
Masero Anodzivirira Dziviriro Paganda Anogona Kusimba Paganda Kupfuura MuRopa, Majekiseni Asingasviki Netsono Ramangwana?
Anonim

Masayendisiti akambofunga kuti immune system's memory T masero, anodzivirira muviri nekuziva vapikisi vekunze senge mabhakitiriya, mavhairasi uye maseru egomarara kudzivirira kutapukirwazve, aivepo zvakanyanya muropa nemalymph nodes, asi tsvakiridzo yazvino inoratidza kuti ndangariro yekugara. T masero, masero endangariro akapararira muganda, anogona kunge akasimba zvakanyanya kupfuura kutenderera ndangariro T masero.

Ongororo yazvino yakaburitswa neChitatu mujenari Nature, inoratidza kuti chikamu chakakosha che immune system yemunhu chinogona kunyatsogara mukati memuviri kana epithelial tishu, uye kubaiwa kuburikidza neaya matishu, seganda, gastrointestinal turakiti, mapapu anogona kukonzeresa. mhinduro yakasimba kwazvo yekudzivirira muviri kupfuura kutenderedza ndangariro T masero muropa.

Chidzidzo ichi, chakatungamirwa nevatsvagiri Xiaodong Jiang, Rachael Clark naThomas Kupper veBrigham neChipatara chevakadzi muBoston vakaenzanisa masero emundangariro T achipesana nekutenderedza ndangariro T masero mumakonzo kuti aone kuti ndeupi rudzi rwesero rekudzivirira rakanyanya kushanda mukurwisa kutapukirwa zvakare.

Chikwata chakatapurira mapoka matatu akasiyana emakonzo emurabhoritari neutachiona humwe chetehwo hwejekiseni, chikamu chikuru chemushonga wenhomba. Boka rekutanga mbeva raive nesese kutenderera ndangariro maseru uye ganda rekugara ndangariro masero, uye rechipiri uye rechitatu boka raive neinotenderera kana yekugara ndangariro maseru.

Vatsvagiri vakabva vafumura mhando yega yega yegonzo nehutachiona hwevaccinia zvakare kuti vaone kuti ndeupi rudzi rwendangariro T cell yakaunza mhinduro inoshanda yekudzivirira.

"Maseru endangariro anogara akahwina maoko," Kupper akaudza The Scientist Magazine. “Kwakanga kusiri kana makwikwi. Vanoshanda zvakanyanya.”

Iwo mapoka maviri emakonzo ane anoshanda anogara ndangariro T masero akange abvisa hutachiona mumazuva matanhatu, zvisinei nekuti anotenderera ndangariro T maseru aivepo. Nekudaro mbeva dzaingotenderera ndangariro T masero akatora mazuva makumi maviri, kanopfuura katatu nguva yemamwe mapoka maviri kubvisa hutachiona.

Vatsvagiri vakati mhedzisiro yacho inoratidza kuti mbeva dzaingove nemasero ekutenderera endangariro T dzakangokurumidza kupora kubva kuhutachiona zvichienzaniswa nembeva dzekudzora dzisina kumbobvira dzasangana nehutachiona uye dzakatora mazuva makumi maviri neshanu kubvisa hutachiona.

Vatsvakurudzi vakawanawo kuti mushure mekutapukirwa, mugari wekuyeuka T masero aigara kwete chete panzvimbo yehutachiona hwehutachiona, asi akapararira munzvimbo dzose dzeganda uye akagara kwemwedzi mitanhatu. Humwe hutachiona huzhinji muganda hwakakonzera kuunganidzwa kwemamwe anogara endangariro T maseru nguva yega yega.

Dzimwe nyanzvi dzinotaura kuti zvakawanikwa kuti huwandu hwevanhu vakasimba ndangariro T masero anowanikwa munhengo dzekunze ainyanya kushanda kupfuura kutenderedza ndangariro masero edziviriro akaita zvine musoro nekuti ari munzvimbo dzisina njodzi dzemuviri dzinosangana zvakanyanya nenharaunda.

"Munguva yakapfuura, vanhu vakaita zviyedzo zve vivo zvinoratidza kuti mugari wekuyeuka uye kutenderera masero endangariro anopa kudzivirirwa kwakafanana," Onur Boyman, chiremba wezvirwere zvekudzivirira zvirwere paYunivhesiti yeZurich uyo akamboona mamwe ekutanga anogara ndangariro T masero paganda. 2004, akaudza The Scientist. "Iri bepa rinopa nhanho yakanaka kumberi mukuratidza kuti aya masero endangariro anogara anoshanda zvakanyanya kurwisa hutachiona hweganda kana zvichienzaniswa nepakati ndangariro maseru."

Muna 2006 Clark naKupper vakawanawo ruzhinji rwevanhu vanogara mundangariro T masero muganda rakajairwa rinokwanisa kukonzeresa nekuchengetedza maitiro ekudzivirira emuviri pakange pasina anotenderera T masero muropa, uye muna 2011, vakawana zvakare yaivapowo mumapapu.

Kupper akatsanangura aya masero endangariro T anogona kunge ari munhengo dzedu dzepedyo nekuti matishu aya ndiwo mutsara wekutanga wekudzivirira kubva kuhutachiona.

"Chirwere chekudzivirira muviri chinopa masero eT akakodzera, panzvimbo yakakodzera uye nguva, kutidzivirira kubva kune imwe nzvimbo izere nehutachiona hunogona kukuvadza." Kupper akadaro mune chirevo chakaburitswa neChitatu.

Akataura kuti zvichangobva kuwanikwa zvakasimbisawo kushanda kwemamwe majekiseni ekudzivirira ekudzivirira ayo anoendesa majekiseni kunzvimbo dzepamusoro dzeganda dzakaongororwa mumhando dzepreclinical, dzakaratidzwa kuve dzakanyanya kushanda kune akajairwa jekiseni rekudzivirira mumhasuru dzeropa.

"Kuisa tsvakiridzo iyi munhoroondo, inobatsira kutsanangura kushanda nesimba kwemushonga wekutanga wakabudirira wakagadzirirwa chibhokisi naJenner muna 1796," Kupper akadaro. "Majekiseni akange asati agadzirwa, saka Jenner akapa jekiseni rekutanga nekuvhiringa mativi epamusoro eganda netsono yakasarudzika, maitiro akafanana nemafambisirwo akaitwa utachiona hwejekiseni mutsvakurudzo yedu. Zvakakosha kuyeuka kuti jekiseni rekudzivirira chibhokisi rinoramba riri iro mushonga unoshanda zvakanyanya munhoroondo yekurapa, zvichikonzera kubviswa kwechibhokisi muhuwandu hwevanhu."

"Majekiseni emazuva ese anowanzo tarisa pakugadzirisa B cell ruoko rwe immune system kuti igadzire masoja ekurwisa zvirwere. Kusiyana neizvi, chidzidzo ichi chinoratidza kuti nzira inoshanda yekudzivirira hutachiona inogona kunge iri yekubatanidza chikamu chichangobva kuwanikwa cheT cell ruoko rwe. immune system kuburikidza nehuwandu hwemaseru ane simba atinoziva anogara muganda, mapapu, ura, uye mamwe epithelial tishu, "Kupper akawedzera.

Yakakurumbira nenyaya