Kuwanikwa Kutsva: Kushungurudzika Kunoderedza Brain's Plasticity
Kuwanikwa Kutsva: Kushungurudzika Kunoderedza Brain's Plasticity
Anonim

Munguva yekuora mwoyo, uropi hunova hushoma hwepurasitiki uye hunogadziriswa, uye nokudaro husingakwanisi kuita mamwe mabasa, sekuchengetedza ndangariro. Vatsvagiri vepaKarolinska Institutet parizvino vakatsvaga kuderera kwepurasitiki yehuropi kuderera kushanda mumaseru ayo ekutsigira, uye vanotenda kuti kudzidza zvakawanda nezvemasero aya kunogona kugadzira nzira yekurapa kutsva kwekuora mwoyo.

"Takakwanisa kurapa kusashanda zvakanaka kwendangariro mumakonzo 'akaora mwoyo' nekuvapa dosi yeD-serine," anodaro Mia Lindskog, biologist uye Assistant Purofesa kuKarolinska Institutet's Dhipatimendi reNeuroscience.

Dr Lindskog nechikwata chavo vakashandisa makonzo eFSL, ari makonzo akanyatso kuchengetwa ane “depression”. Makonzo akatanga kuiswa kuburikidza nemiedzo miviri yekusimbisa kuti vaive nezviratidzo izvo zvakare hunhu hwekuora mwoyo kwevanhu. Mukutanga, ndangariro dzemakonzo dzaiongororwa nokudzokororwa kuratidzwa kuzvinhu zvakasiyana; kechipiri, timu yakaongorora huwandu hwavo hwekusakendenga nekuvaburitsa mumudziyo wemvura uye nekuona kuti vakaramba vachiyangarara mumudziyo here kana kuti vakaedza kukwira kunze (kwete remakonzo aifanira kugara mumvura kweanopfuura mashanu. maminitsi). Muzviitiko zvese izvi mhedzisiro yemakonzo eFSL yakaenzaniswa nemakonzo emurabhoritari akajairwa, uye kusagadzikana kwendangariro nekusakendenga zvinogona kusimbiswa.

Vatsvakurudzi vakabva vabaya makonzo neD-serine. Chinhu ichi chakavandudza ndangariro dzavo asi chakashaya basa pakusakendenga.

"Takaratidza kuti pane zviratidzo zviviri pano zvinogona kupesvedzerwa pasina mumwe, zvinoreva kuti zvinogona kurapwa pamwe chete nevarwere vane depression," anodaro Dr Lindskog.

Vatsvagiri vakadzidzawo chiitiko chesynaptic muhippocampus yemakonzo, chikamu chehuropi chinoita chikamu chakakosha mundangariro. Vakaona kuti pakanga paine dhigirii yakakwira kwazvo yesynaptic chiitiko muhuropi hwemakonzo akaora mwoyo kupfuura mukutonga. Zvisinei, apo vatsvakurudzi vakaedza kuwedzera chiyero chekutapurirana kwechiratidzo, vakawana huropi hwemakonzo akaora mwoyo husingateereri, izvo zvakaratidza kuti vaiva nepurasitiki yakaderera yakaita kuti vasakwanise kuwedzera neuronal basa kana zvichidiwa - kusiyana nehuropi hwe makonzo ane utano. Apo sampuli dzehuropi dzakanyoroveswa muD-serine, huropi hwemakonzo akaora mwoyo hwakavandudzika.

D-serine chinhu chakavanzwa neastrocyte, ari maseru anotsigira europi neurons.

"Hatizive zvakanyanya nezve masero aya, asi zvine mukana wekuti anoita basa rakakosha muuropi," anodaro Dr Lindskog.

Kunokarirwa kuti zvavanowana pakupedzisira zvichatungamirira kumishonga mitsva yokuora mwoyo.

"D-serine haipfuure chipingamupinyi cheropa-uropi zvakanyanya, saka haisi mumiriri akakodzera wekuisa mushonga, asi nzira yatakaona, iyo inogoneka kuwedzera plasticity nekuvandudza ndangariro, inzira inogoneka yatinokwanisa kusvika nenzira isingasanganisire D-serine," anodaro Dr Lindskog.

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