Micro-RNA inosarudza kuipa kwekenza yemapapu
Micro-RNA inosarudza kuipa kwekenza yemapapu
Anonim

Kenza inoisa hupenyu panjodzi kana bundu masero atanga kusiya nzvimbo yavo yekutanga. Vanofamba kuburikidza ne lymph uye nzizi dzeropa kuenda kune mamwe matishu kwavanokura kuita metastases. Kuchinja uku kune hutsinye hunoenderana nekuchinja kwehunhu mumasero egomarara. Chiitiko chemajini akati wandei chinorongwa patsva uye, nekudaro, kugadzirwa kwemapuroteni anomisa maseru kumatishu kunoderedzwa. Kune rimwe divi, huwandu hwemamaki epamusoro anoita kuti kenza cell mobile inowedzera.

Purofesa Dr. Heike Allgayer anotungamira Clinical Cooperation Unit yeDKFZ neUMM. Iye inyanzvi yeaya maserura maitiro anotungamira kune metastasis mugomarara. Mumakore achangopfuura, masayendisiti akawana kuti kugadzirwa kwemapuroteni akawanda kunodzorwa neanonzi mamicro-RNA. Aya mamorekuru eRNA, anongosanganisira zvivharo makumi maviri nenhatu chete, anonamira kune mamessenger RNAs, ane mapurani emapuroteni. Nenzira iyi, ivo vanovhara kugadzirwa kweprotein inoenderana.

"Tinotenda kuti maMicro-RNA anoitawo basa rakakosha mumetastasis uye kuti anoronga maseru nenzira inotungamira mukukura kwakashata," muongorori wezvekurapa Heike Allgayer anotsanangura. Mukubatana nedzimwe nyika nevatsvakurudzi muTurin, Italy, Allgayer nechikwata chake vakashandisa mitsara yakasiyana siyana yegomarara remapapu risiri diki kuferefeta munhu anonyanya kufungidzira anonzi miR-200c nebasa rayo mukukura kwakashata. Chikwata chekutsvagisa chakaona kuti iyo miR-200c shoma inogadzirwa nesero mutsara, iyo inokwirisa motility yayo uye kugona kwayo kupinda nechisimba tishu dzakatenderedza. Vatsvagiri pavakayedza kugadzirira maseru egomarara nekuwedzera miR-200c, huwandu hwematishu-anchoring mamorekuru ari pamusoro pavo akawedzera uye simba ravo rekupinda rakadzika. Mukuedza kwemhuka, masero aya akabudisa metastasis shoma.

Chinhu chinotyisa chegomarara remapapu risiri diki ndiko kuramba chemotherapy nemishonga inorwisa cancer. Kushaikwa kwe miR-200c kunoratidzikawo kuita basa pano. Mitsara yekenza yemapapu isingarapike iyo yakashongedzerwa miR-200c inogona kuzourayiwa nechemotherapy drug cisplatin ndokudaira kucetuximab, mushonga unovhara masaini ekukura.

Allgayer's Team yakaonawo kuti kurasikirwa kwe miR-200c kunounzwa sei mumaseru egomarara. Mumasero ane hukasha, iwo miR-200c majini anodzimwa nekemikari kunyora nemapoka emethyl. Mishonga inobvisa mavara aya yakaita kuti kugadzirwa kwe miR-200c kusimuke zvakare.

Kudzidza masero emamota e69 varwere vekenza yemapapu, vaongorori vakaona kuti miR-200c haingoite basa mundiro yetsika. Vakasarudza miR-200c mazinga uye vakaenzanisa aya nevarwere'chirwere chekukura data. Iyo yakadzikira iyo miR-200c nhanho mumaseru egomarara, iyo yakawedzera metastasis yaive yatotanga. "Mibairo yedu inonyatso ratidza kubatana pakati pekurasikirwa kwe miR-200c uye shanduko kune hukasha, invasive kukura, metastasis uye chemoresistance," Heike Allgayer anopfupisa. "Naizvozvo, isu tichaongorora ikozvino kana miR-200c kugadzirwa mumaseru egomarara inogona kushandiswa kufanotaura metastasis uye, nekudaro, inogona kushanda sechiratidzo chekufambira mberi kwegomarara remapapu. Zvinogoneka zvakare kuti iyo miR-200c level inogona kubatsira kufanotaura zvirinani kushanda kweimwe mishonga."

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