Genetic risk score yakabatana nengozi yekenza yemazamu; kufanotaura kwerudzi rwechirwere
Genetic risk score yakabatana nengozi yekenza yemazamu; kufanotaura kwerudzi rwechirwere
Anonim

Vakadzi vane mikana yepamusoro yengozi yaisanganisira kuve nemamwe marudzi akasiyana-siyana ane hukama zvakanyanya negomarara rezamu vaive nenjodzi yakakwira yegomarara rezamu, uye zvibodzwa izvi zvakare zvakafanotaura nezveestrogen receptor-positive chirwere, sekureva kweongororo yakabuda muna Chikunguru 28. JAMA.

"Zvakawanikwa kubva muzvidzidzo zvegenome-wide association (GWAS), pamwe chete neongororo yezvakasiyana-siyana zvemapolymorphisms [kusiyana kwemajini], zvakaratidza zvakasiyana-siyana zvinonyatsobatanidzwa kana kuti zvichida zvine chokuita nengozi yegomarara rezamu. vane mhedzisiro dzakasiyana pamhando dzakasiyana dzegomarara rezamu," vanyori vanonyora.

Gillian K. Reeves, Ph.D., weCancer Epidemiology Unit, University of Oxford, UK, uye vaaishanda navo vakaita chidzidzo chekuongorora njodzi yekenza yemazamu, yakazara uye nebundu subtype, maererano ne14 yega-nucleotide polymorphisms (SNPs).;) uye polygenic (inechekuita nehunhu hunogarwa nhaka hunodzorwa nemajini akati wandei panguva imwe) njodzi yengozi. Chidzidzo chacho chaisanganisira 10, 306 vakadzi vane kenza yemazamu (avhareji yezera pakuongororwa, makore makumi mashanu nemasere) uye 10, 393 vakadzi vasina kenza yemazamu, avo muna 2005-2008 vakapa samples yeropa ye genotyping. Vatsvagiri vakafungidzira iyo per-allele odds ratio (OR) yemunhu ega SNPs uye kuwanda kwekenza yemazamu kusvika pazera 70 makore zvine chekuita nepolygenic njodzi chibodzwa chakavakirwa pane 4, 7, kana gumi SNPs zvakanyanya hukama nenjodzi.

Vatsvagiri vakawana kuti kusawirirana kwekenza yemazamu kwaive kwakakura kune SNPs FGFR2-rs2981582 uye TNRC9-rs3803662 uye, kune idzi 2 SNPs, yaive yakakura zvakanyanya kune estrogen receptor (ER) -yakanaka pane yeER-negative chirwere, zvese mu data yechidzidzo ichi uye mune meta-kuongorora yeimwe data yakadhindwa. Kubatana kwakasimba kwakatevera kwaive kwe2q-rs13387042, iyo per-allele OR yaive yakakura zvakanyanya kune bilateral pane unilateral chirwere uye ye lobular kupfuura ductal tumors.

"Apo mhedzisiro ye7 SNPs yakabatana zvakanyanya nenjodzi yekenza yemazamu mune idzi data yakasanganiswa uchishandisa polygenic njodzi yekenza, njodzi yekuwedzera yekenza yemazamu kusvika makore makumi manomwe pakati pevakadzi vepamusoro pechishanu yakapetwa kaviri pazasi yechishanu. (8.8 muzana vs. 4.4 muzana).Zvese hama uye, kunyanya, mutsauko wakakwana wakanga wakakura zvikuru kune ER-positive chirwere (7.4 muzana vs. 3.4 muzana) pane yeER-negative chirwere (1.4 muzana vs. 1.0 muzana), " vanyori vanonyora.

"Muchidzidzo chikuru ichi chinosanganisira 10, 306 vakadzi vane gomarara rezamu uye 10, 393 vasina chirwere ichi, tinosimbisa kuti mamwe emhando dzakanyanya kukosha dzakasiyana dzegomarara rezamu dzine mhedzisiro dzakasiyana pamhando dzakasiyana dzebundu."

"Dzimwe dzakasimbiswa dzengozi dzegomarara rezamu dzine mhedzisiro yakafanana, kana kutonyanya, pachiitiko chegomarara rezamu pane misiyano inoonekwa pano pakati pevakadzi vepamusoro-soro vs. yakaderera yechishanu yepolygenic risk score. Chokwadi, fungidziro yedu yekuwedzera kwechiitiko chezamu. kenza kusvika pazera remakore makumi manomwe muvakadzi vari muchikamu chechishanu chepolygenic ngozi (8.8 muzana) yakafanana neyevakadzi vari munyika dzakabudirira vane imwe dhigirii yekutanga ine kenza yemazamu (9.1 muzana), uye zvishoma pane iyo yevakadzi vane 2 vakakanganisa vekutanga-degree hama (15.4 muzana) Uyezve, hapana kudyidzana kwakawanikwa pakati pemhedzisiro yemajini akaongororwa pano uye zvimwe zvinokonzeresa njodzi yegomarara rezamu.Nekudaro, sezvakataurwa nevamwe, kupatsanura vakadzi nechikonzero che polygenic yavo. Ngozi, panguva ino, haisi chishandiso chinobatsira chezvirongwa zvekuongorora kenza yemazamu asi inogona kubatsira pakunzwisisa nzira dzechirwere, "vanopedzisa vanoongorora.

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