Calcium yekubatanidza: Nzira yekutanga yekuchengetedza zvitoro zvemafuta
Calcium yekubatanidza: Nzira yekutanga yekuchengetedza zvitoro zvemafuta
Anonim

University of Pennsylvania Chikoro cheMishonga vatsvakurudzi vakatsanangura nzira yaimbozivikanwa yebhaibheri mumaseru inovadzivirira kubva pakuzvidya ivo pachavo mafuta. Iyo meshini inosanganisira mafuta anoshandiswa nemaseru pasi pemamiriro akajairwa uye anovimba nekufambiswa kunoenderera kwecalcium pakati pezvikamu zviviri zvemasero kuburikidza neion chiteshi. Pasina kutamiswa uku, maseru anotanga kuzvidya senzira yekuwana simba rakakwana.

“Kuchinjwa kwe<em>metabolism chikamu chezvirwere zvakawanda, pamwe chete nokuchembera,” anodaro munyori mukuru J. Kevin Foskett, PhD, purofesa wePhysiology. "Tsanangudzo yeiyi nzira yakakosha yekudzora simba resero ichave nezvainoreva kune akasiyana siyana maitiro emuviri uye zvirwere." Vaongorori vanotsanangura zvavakawana muchinyorwa chebutiro muchinyorwa chazvino cheSero.

Masero mazhinji ane hutano mumuviri anovimba neyakaomeswa maitiro anonzi oxidative phosphorylation kugadzira mafuta ATP. Zivo pamusoro pekuti ATP inogadzirwa sei nesero mitochondria, imba yekuchengetera simba, yakakosha pakunzwisisa yakajairika cell metabolism, iyo ichapa ruzivo mune abnormal cell metabolism, senge nyaya yegomarara.

Foskett nevamwe vaaishanda navo vakawana kuti yakakosha yekudzora sisitimu inodzora ATP kuvharika kunoenderera kwecalcium kuenda kune mitochondria kubva kune imwe sero chikamu chinonzi endoplasmic reticulum.

Iyo endoplasmic reticulum ndiyo huru yekuchengetedza calcium mumasero. Karusiyamu yakachengetwa inoburitswa kune mitochondria iri padyo kuburikidza nemugero we calcium ion unonzi IP3 receptor. Vatsvakurudzi vakawana kuti iyi calcium kusunungurwa kunoitika pamwero wakaderera nguva dzose.

Apo vatsvakurudzi vakavhiringidza kusunungurwa kwe calcium vachishandisa genetic kana pharmacological nzira, mitochondria haina kukwanisa kubudisa ATP yakakwana kuti iite zvinodiwa nesero. Izvi zvinoratidza kuti mitochondria inotsamira pane inoenderera mberi calcium kutamisa kuita ATP yakakwana kutsigira yakajairika cell metabolism.

Mukushaikwa kwekutamiswa uku, mitochondria inotadza kugadzira ATP yakakwana, izvo zvinokonzeresa nzira yekupona yesero inonzi autophagy, kana kuzvidyira.

"Takaona kuti kuzvishandisa semhinduro yekushaikwa kwecalcium kutamiswa kunoratidzika kushanda mumhando dzakawanda dzemasero, kusanganisira hepatocytes kubva pachiropa, vascular smooth muscle masero, uye akasiyana siyana masero mitsara," anodaro Foskett.

Autophagy yakakosha pakubvisa mapuroteni akaunganidzwa kubva mumasero, semuenzaniso muzvirwere zveurourodegenerative, uye inoita basa mugomarara uye hypertension. Iyo IP3 receptor inoita basa rakakosha mukudzora kufa kwakarongwa kwesero, maitiro akapinzwa mumakenza mazhinji, uye muzvirwere zveurourodegenerative, kusanganisira chirwere cheAlzheimer neHuntington. Calcium kuburitswa kubva kuIP3 receptor inogona kunge iri paNexus yeNeurodegeneration, cancer uye basa remasetabolism esero raenda zvakashata mumakirasi echirwere ichi.

Tsvagiridzo iyi yakatsigirwa neNational Institute of General Medical Science, National Heart, Lung, uye Ropa Institute, uye National Institute of Diabetes uye Digestive uye Kidney Zvirwere.

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