Multifunctional nanoparticle inogonesa mhando nyowani yebiological imaging
Multifunctional nanoparticle inogonesa mhando nyowani yebiological imaging
Anonim

Kuona sero rimwe chete regomarara rabuda mubundu uye riri kufamba nemuropa kuti ritore nhengo itsva kungaita sekutsvaga tsono mudura reuswa. Asi nzira nyowani yekufungidzira kubva kuYunivhesiti yeWashington inhanho yekutanga kuita kuti izvi zviitike.

Vatsvagiri veUW vakagadzira nanoparticle inoshanda yakawanda inobvisa ruzha rwekumashure, ichigonesa imwe yemhando yekufungidzira yekurapa - kunyanya kudzima huswa, saka tsono inopenya. Kuratidzira kwakabudirira nemifananidzo ye photoacoustic yakashumwa nhasi (July 27) mumagazini Nature Communications.

Nanoparticles ari kuvimbisa maajenti emusiyano we Ultrasensitive imaging yekurapa. Asi muhunyanzvi hwese husingashandise radioactive tracers, matishu akatenderedza anowanzo kukurira masaini asina simba, achidzivirira vaongorori kuti vaone sero rimwe chete kana mashoma.

"Kunyangwe matishu acho asingaite kunge anoshanda pakugadzira chiratidzo seanosiyanisa, huwandu hwematishu hwakakura kupfuura huwandu hweanosiyanisa uye saka chiratidzo chekumashure chakakwira zvakanyanya," akadaro munyori anotungamira Xiaohu Gao, a. UW mubatsiri purofesa we bioengineering.

Iyo ichangoburwa nanoparticle inogadzirisa dambudziko iri kekutanga kubatanidza zvivakwa zviviri kugadzira mufananidzo wakasiyana nechero nzira iripo yaigona kunge yakagadzira.

Iyo nyowani nyowani inosanganisa magineti zvivakwa uye photoacoustic imaging kudzima ruzha rwekumashure. Vatsvakurudzi vakashandisa pulsing magnetic field kuzunungusa nanoparticles nemagnetic cores. Vakabva vatora mufananidzo wephotoacoustic ndokushandisa matekiniki ekugadzirisa mifananidzo kubvisa zvese kunze kwemapikisi anodedera.

Gao anoenzanisa hunyanzvi hutsva ne "Tourist Remover" software editing software inobvumira mutori wemifananidzo kudzima vamwe vanhu nekubatanidza mafoto akati wandei echiitiko chimwe chete uye kuchengeta chete zvikamu zvemufananidzo izvo zvisiri kufamba. "Tiri kushandisa zano rakafanana," Gao akadaro. "Panzvimbo yekuti tichengete mativi akamira, tinongochengeta chikamu chinofamba.

"Isu tinoshandisa yekunze magineti kuzunza zvidimbu," akatsanangura kudaro. "Zvino pane imwe chete mhando yechikamu chinozunguzika pahuwandu hwemagineti yedu, inova yedu pachedu."

Ongororo nematishu ekugadzira zvakaratidza kuti tekiniki inogona kudzvanya zvachose chiratidzo chakasimba chekumashure. Basa remangwana richaedza kudzokorora mhedzisiro mumhuka dzerabhu, akadaro Gao.

Iyo 30-nanometer particle ine iron-oxide magnetic core ine goko regoridhe rakatetepa rinotenderedza asi risingabati pakati. Iyo goko regoridhe rinoshandiswa kutora infrared mwenje, uye rinogona zvakare kushandiswa kufungidzira optical, kuendesa kupisa kupisa, kana kubatanidza biomolecule yaizobata kune chaiwo maseru.

Kare basa neboka reGao rakabatanidza mabasa mune imwe nanoparticle, chimwe chinhu chakaoma nekuda kwehukuru hudiki.

"Munanoparticles, imwe kuwedzera imwe kazhinji isingasviki maviri," akadaro Gao. "Basa redu rekare rairatidza kuti imwe kuwedzera imwe inogona kuenzana nembiri. Bepa iri rinoratidza kuti imwe kuwedzera imwe, pakupedzisira, yakakura kudarika mbiri."

Yekutanga biological imaging, muma 1950s, yakashandiswa kuona anatomi mukati memuviri, kuona mamota kana mafetus. Chizvarwa chechipiri chakashandiswa kutarisa basa - fMRI, kana kushanda kwemagineti resonance imaging, semuenzaniso, inoona kushandiswa kweokisijeni muuropi kugadzira mufananidzo webasa rehuropi. Chizvarwa chinotevera chekufungidzira chichava kufungidzira kwemamorekuru, akadaro munyori-mumwe Matthew O'Donnell, purofesa weUW we bioengineering uye engineering dean.

Izvi zvinoreva kuti kuongororwa kwekurapa uye maseru kuverenga kunogona kuitwa mukati memuviri. Mune mamwe mazwi, panzvimbo yekutora biopsy uye kuongorora tishu pasi pemaikorosikopu, kufungidzira kunogona kuona mapuroteni chaiwo kana chiitiko chisina kujairika panzvimbo yacho.

Asi kuita kuti izvi zviitike zvinoreva kuvandudza miganhu yekuvimba yekufungidzira.

"Nhasi, tinogona kushandisa biomarkers kuona pane muunganidzwa wakakura wemasero anorwara," akadaro O'Donnell. "Iyi nzira nyowani inogona kukudzikisa iwe kusvika padanho chairo, ringangoita sero rimwe chete."

Vatsvaguri vakaedza nzira yekufungidzira kwefotoacoustic, nzira ine mutengo wakaderera iri kugadzirwa iyo inonzwikwa nekusiyana kushoma kwezvivakwa zvetishu uye inogona kupinda mukati memasendimita akati wandei munyama yakapfava. Inoshanda nekushandisa pulse yelaser light kupisa sero zvishoma. Kupisa uku kunoita kuti sero rizungunuke uye ribudise masaisai e<em>ultrasound anofamba nemumatishu kuenda pamusoro pemuviri. Iyo nzira nyowani inofanirwawo kushanda kune mamwe marudzi ekufungidzira, vanyori vakadaro.

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