Mapuroteni akaonekwa anogona kukonzera mapfupa asina kusimba
Mapuroteni akaonekwa anogona kukonzera mapfupa asina kusimba
Anonim

Kunyanya kushoma kweprotein inonzi neogenin inokonzeresa skeleton diki panguva yekuvandudzwa uye inogadzirisa nhanho yehumwe hutete hwemapfupa hupenyu hwese, Medical College yeGeorgia vaongorori vanoshuma.

A mbeva iri kusimukira ine neogenin deficits ine madhijitari asina kutsanangurwa uye kazhinji idiki, kusanganisira kuva nemapuleti madiki ekukura, chiratidzo chebudiriro mune ramangwana, akadaro Dr. Wen-Cheng Xiong, anovandudza neurobiologist muMCG Zvikoro zveMishonga uye Graduate Zvidzidzo uye anowirirana munyori we chidzidzo chakabudiswa muDevelopment Cell. Dr. Zheng Zhou, mutevedzeri weMCG musayendisiti wekutsvakurudza, ndiye munyori wekutanga.

Zvavakawana zvinopa ruzivo rutsva mukukura kweskeletal sezvavanonongedza kune imwe nzira itsva yekurapa osteoarthritis, inowanzoitika, inorwadza uye inopedza simba apo cartilage pakati pemapfupa inorasika, Xiong akadaro.

Neogenin haigadziri pfupa; asi, inoumba puroteni yakaoma yakakosha kutendeutsa majene-anoburitsa majene, vaongorori vakawana. "Rudzi rwesero rimwe nerimwe rine master gene. Neogenin haisi iyo, yakawanda ye modulator, " Xiong akati. Ndokusaka, kana ikashandurwa, senge mbeva, cartilage uye kuumbwa kwebhonzo kunokanganiswa - kwete kumiswa. Ndicho chikonzero nei neogenin inogona kuva yakanaka yekurapa chinangwa chekushandura mafambiro pane cartilage kana kurasikirwa kwepfupa kunoitika mune osteoarthritis, Xiong akadaro.

Skeletal kukura kunoitika kare, ndicho chikonzero vakadzi vane pamuviri vanoda calcium yakawanda. Pakutanga skeleton ine bhonzo rakapfava kana shwashwa, iro rinokwezva tsinga dzeropa pamwe chete neosteoblasts inotsiva shwashwa zhinji nemapfupa akaomarara nekufamba kwenguva. Mushure mokuberekwa, mahwendefa ekukura, apo mapfupa akaoma uye akapfava anosangana, anoita kuti mapfupa arebe uye vana vakure. Mushure mekuyaruka, mahwendefa ekukura anoenda uye bhonzo rinooma kunze kwekashwa pamajoini iyo inorerutsa kufamba uye inopa cushion. Nepo masero emapfupa achiramba achitendeuka, kukura kwepfupa uye kurasikirwa kunofanirwa kuenzana mushure mekuyaruka nekuda kwe osteoclasts - masero anoputsika uye anodzoreredza pfupa. Zvirwere zvakaita seosteoporosis uye osteoarthritis zvinoitika apo osteoclasts inotanga kuhwina. Zvokudya, kuzvimba uye mahomoni ndezvimwe zvezvinhu zvakawanda zvinokanganisa chimiro chebhonzo.

Neogenin, iyo Xiong yakaratidza inobatsira kutungamira neurons panguva yekukura kwehuropi uye rubatsiro mukudzora nhanho dzesimbi, inowanikwa mubhonzo uye cartilage uye akati wandei mamwe matishu. Kupararira kwayo kunoratidza mabasa ayo mazhinji, zvichienderana nedanho rehupenyu nenzvimbo, akadaro.

Xiong anofungidzira kuti puroteni ine mabasa akati wandei mukukura zvakare, kunyangwe akasiyana zvishoma. Mukukura, neogenin inogona kuve yakawanda yemutariri, ichichengeta mabheti pamabasa ayo anopesvedzera, sekuumbwa kwemapfupa. Inotangazve basa rekukurudzira kana chimwe chinhu chikaitika.

"Chese basa riri mumuviri rinoda kukwanisa kukwira kana pasi," Xiong akadaro, achiona kuti neogenin nzira dzinogona kuchinjwa muchirwere. "Ini ndinofunga mumamiriro echirwere ichi molecule inogona kuchinjwa. Nzira dzinoshandurwa, kwete kubviswa, pane kuwedzera kana kuderera zvisina kufanira."

Kurapa matambudziko akadai seosteoporosis, iron overload uye anemia, zvingada mishonga inogona kuchengetedza mapuroteni akakwira. Zvichakadaro, anoda kusimbisa pesvedzero ye neogenin pane cartilage basa mukukura. "Mukati mekupedzisira-arthritis, iyo cartilage basa inogona kuvhiringidzika zvachose asi pakutanga kwechirwere chechirwere, zvichida pane hwindo rekukurudzira puroteni iyi."

Yakakurumbira nenyaya