Varume vazhinji vane gomarara reprostate rine njodzi shoma vanorapwa zvine hasha
Varume vazhinji vane gomarara reprostate rine njodzi shoma vanorapwa zvine hasha
Anonim

Varume vazhinji vanobatwa nekenza yeprostate vanoita kunge vari kurapwa zvine hukasha, kunyangwe vaine yakaderera prostate-specific antigen (PSA) uye ine njodzi yakaderera chirwere, sekureva kweshumo muChikunguru 26 chinyorwa cheArchives of Internal Medicine, imwe yemagazini eJAMA/Archives.

Inopfuura 90 muzana yekenza yese yeprostate inoongororwa chirwere chisati chapararira kune dzimwe nhengo dzemuviri, uye makore mashanu ekupona kwevarwere ava vanoonekwa kuti vane chirwere chemunharaunda inenge 100 muzana, maererano nemashoko ezvakaitika munyaya yacho. Kurarama kwemakore mashanu kubva pamatanho ose ezvirwere kwakawedzera kubva pa69 muzana muna 1975 kusvika kunenge 99 muzana muna 2003. "Kunatsiridza kukuru kwekupona kwave kuchikonzerwa nekukurumidza kuonekwa uye kurapwa," vanyori vanonyora kudaro. "Zvisinei, pave nekunetsekana pamusoro pekugona kuwedzeredza uye kuwandisa kwekenza yeprostate yemuno. Pasinei nekunetseka uku, vamwe vatsvakurudzi vanopikisa kuti prostate-specific antigen (PSA) level inobatanidzwa nekuenderera mberi kwekenza yekenza uye inokurudzira kuderedza 4-nanogram. pa millilita chikumbaridzo chebiopsy."

Kuti vatarise mamiriro azvino engozi uye maitiro ekurapa kwevarume vane cancer yeprostate uye mazinga ePSA ari pazasi pechikumbaridzo ichi, Yu-Hsuan Shao, Ph.D., weCancer Institute yeNew Jersey, New Brunswick, nevamwe vaaishanda navo vakashandisa data kubva kuSurveillance, Epidemiology. uye End Migumisiro system. Pakati pevarume 123, 934 vane kenza yeprostate ichangobva kuwanikwa kubva muna 2004 kusvika muna 2006, 14 muzana vaiva nePSA mazinga e4 nanograms pa milliliter kana pasi. "Varwere vari muzviitiko izvi vaisanyanya kuve nekenza yepamusoro-giredhi, uye vanopfuura hafu vakarongedzerwa kunge vane kenza yakaderera," vanyori vanonyora.

"Pasinei nengozi yavo yakaderera yekuva nechirwere chekiriniki, mitengo yekurapa kwevarume vane PSA tsika dze4.0 nanograms pa milliliter kana yakaderera yakaenzana neyevarume vaiuya nePSA tsika pakati pe4.0 ne20.0 nanograms pa millilita." Vanopfuura makumi manomwe muzana vevarume vane PSA hunhu hwakaderera pane makumi maviri nanograms pamillilita vakabviswa prostates kuburikidza neradical prostatectomy kana kurapwa nemwaranzi. "Radical prostatectomy yakaitwa pa44 muzana yevarume vane PSA tsika dze4.0 nanograms pamilliliter kana pasi, 38 muzana yevarume vane PSA inokosha pakati pe4.1 ne10.0 nanograms pamilliliter uye 24 muzana yevarume vane PSA inokosha pakati pe10.1 ne20 nanograms pamilliliter..Radiation therapy yakaitwa pa33 muzana yevarume vane PSA values ​​dze4.0 nanograms per milliliter kana pasi, 40 percent yevarume vane PSA values ​​between 4.1 and 10.0 nanograms per milliliter and 41.3 percent yevarume vane PSA values ​​between 10.1 and 20 milliliter," vanyori vanonyora.

Vanyori vanoratidza kuti kana chikumbaridzo chePSA kukosha kwebiopsy chakadzikiswa kubva pa4.0 kusvika 2.5 nanograms pamillilita, nhamba yevarume vane mazinga ePSA asina kujairika yaizopeta kusvika pamamiriyoni matanhatu. "Kufungidzira kunoratidza kuti 32 muzana yevarume vane mazinga ePSA asina kujairika vangaonekwa vaine kenza yeprostate kubva patsono yavo," vanonyora kudaro. "Kubva pane zvakabuda muchidzidzo chezvino, 82.5 muzana yevarume ava mamiriyoni 1.9 vaizowana kuedza kurapa kurapwa, asi 2.4 muzana chete vaizova nekenza yepamusoro. Zvisinei, hapana uchapupu hunoratidza kuti kunonoka biopsy kusvika PSA level yasvika 4.0 nanograms pa. milliliter yaizoguma nenhamba yakawandisa yezvirwere zvisingarapike."

"Izvi mhedzisiro zvinosimbisa chokwadi chekuti PSA level, iyo yazvino biomarker, haisi hwaro hwakakwana hwesarudzo dzekurapa," vanyori vanopedzisa. "Pasina kugona kusiyanisa indolent kubva kune ane hutsinye kenza, kudzikisa biopsy pachikumbaridzo kunogona kuwedzera njodzi yekuwedzeredza uye kuwandisa."

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