Ruzivo rwekumisikidzwa kwemushonga waParkinson wawanikwa
Ruzivo rwekumisikidzwa kwemushonga waParkinson wawanikwa
Anonim

Varwere vanorwara nechirwere cheParkinson vanogona kutarisira kudivi-effect free version yemishonga yavo yedopamine (Levodopa) mune ramangwana risiri kure-kure.

Vatsvakurudzi vanobva kuYunivhesiti yeLund muSweden vakabudirira kubuda nenzira yekuona nzira iri muuropi iyo inonzi inokonzera izvi zvinokonzerwa neLevodopa, imwe yemishonga inowanzoshandiswa kurapa zviratidzo zvine chokuita nechirwere cheParkinson.

Mushonga wacho une shanduro yakagadzirwa nemunhu yekemikari yeuropi dopamine iyo inogona kubatsira mukudzora mafambiro asingadiwi pakati pevarwere vane chirwere cheParkinson, chirwere chetsinga chinokonzera kuoma uye kuzununguka kwemakumbo.

Tsvagiridzo yakaratidza kuti kushandiswa kwenguva refu kwe dopamine kunogona kukonzera mhedzisiro senge yekusazvibata uye jerky mafambiro anozivikanwa mukurapa seDykinesias. Nekudaro, hapana kujeka pane izvo chaizvo zvinokonzeresa maitiro akashata aya.

Kusvika pari zvino, vaongorori havana kukwanisa kuona nzira yakakodzera yekuongorora mashandisirwo acho nekushandisa mhuka dzemurabhoritari. Boka rekudzidza paYunivhesiti yeLund rauya neimwe nzira nyowani yekunyatso ratidza magadzirirwo ehuropi anotungamira kune maside-effects.

“Tinoshandisa utachiona husingakuvadzi hunopinza jena duku mumasero etsinga. Mukuita kunosanganisira matanho akati wandei, geni rinoita kuti masero etsinga arege kuburitsa dopamine, asingaaparadze, "anotsanangura kudaro Ayse Ulusoy, mumwe wevaongorori vakapinda muchirongwa ichi.

Pakati pevarwere vehosha yeParkinson, mamwe masero etsinga anogadzira dopamine anogona kufa. Panguva imwe cheteyo mamwe masero akasiyana-siyana aripo uropi hunoita sehunochinja. Uku kutamiswa kwemabasa nekuda kwekufa kwe dopamine kuburitsa masero ehuropi kunoita kuti kuona kwekuchinja kunotungamira kune dyskinesias kwakaoma.

Masayendisiti akagadzira masero etsinga erabhoritari yemakonzo ayo anowanzo shanda zvakajairika. Aya masero etsinga anogona kuvabvumira kuti vavhure mashandiro ari kuseri kwedyskinesias kwavakawana chinongedzo kumasero etsinga anogona kuburitsa dopamine.

Muchidzidzo ichi, chinowanikwa mupepanhau PNAS (Proceedings of the National Academy of Sciences), vatsvakurudzi vanoratidza kuti zvakawanikwa zvichabatsira mukugadzira kurapa kwakanyanya-kune mutsa kwechirwere cheParkinson munguva pfupi iri kutevera.

Yakakurumbira nenyaya